What specific warning must be included on labels of OTC products for systemic use?

For over-the-counter (OTC) products intended for systemic use, it is important to include specific warnings to ensure the safe use of these medications. The correct choice highlights the necessary warning regarding protection for pregnant women, which addresses a critical aspect of public health.

The inclusion of such a warning on OTC product labels is essential because many systemic medications can have implications for fetal development and pregnancy. Regulatory agencies like the FDA require that these warnings are clear to inform users about potential risks involved in using these products during pregnancy. This helps pregnant women make informed decisions about purchasing and using the medication, considering the potential effects on both their health and that of the fetus.

Other options may pertain to specific populations or safety concerns but do not address the particular needs of pregnant women, making this warning especially significant in the context of systemic OTC products.