What type of medication is considered ineffective for treating nocturnal leg cramps in over-the-counter formulations?

Quinine is considered ineffective for treating nocturnal leg cramps in over-the-counter formulations because it was historically used for this purpose but has since been deemed unsafe for such use by the FDA. The agency has issued warnings about the risks associated with quinine, including serious side effects like thrombocytopenia and severe allergic reactions. The lack of approval for over-the-counter use reflects its associated risks, leading to the conclusion that it is not a recommended treatment for leg cramps.

In contrast, ibuprofen is a nonsteroidal anti-inflammatory drug that can help alleviate pain associated with cramps, while diphenhydramine is an antihistamine that may help with muscle relaxation due to its sedative effects. Hydrocodone is an opioid pain reliever that can also be effective in managing pain, albeit not typically used specifically for leg cramps. Thus, all these alternatives remain within the bounds of safety or have recognized analgesic properties, unlike quinine.